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Clinical Publications
Access information on drug therapy issues impacting today's health care and pharmacy environment. Within the category filter below select Rx Highlights, Rx News, and Rx Outlook to view the latest publications. Rx News can also be filtered by Type or use the search to look for the drug by name.
Optum Rx news and resources (433)
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October 31, 2025
RxNews - October 31, 2025
Revuforj® (revumenib) – New indication
Winrevair™ (sotatercept-csrk) – Updated indication
Blenrep® (belantamab mafodotin-blmf) – New drug approval
Contepo® (fosfomycin) – New drug approval
Javadin™ (clonidine) – New drug approval
Lynkuet® (elinzanetant) – New drug approval
Merck – Discontinuation of Zepatier® (elbasvir/grazoprevir) tablet
Premarin® (conjugated estrogens) – First-time generic
October 24, 2025
RxNews - October 24, 2025
Gazyva® (obinutuzumab) – New indication
Rybelsus® (semaglutide) – New indication
Rytary® (carbidopa/levodopa) – First-time authorized brand alternative
Tezspire® (tezepelumab) – New indication
Xeljanz® (tofacitinib) – Expanded indication
Ravicti® (glycerol phenylbutyrate) – First-time generic
October 17, 2025
RxNews - October 17, 2025
Libtayo® (cemiplimab-rwlc) – New indication
Olpruva® (sodium phenylbutyrate) – Updated indication
Rinvoq® (upadacitinib) – Updated indications
Simponi® (golimumab) – Expanded indication
Uzedy® (risperidone) – New indication
Lasix® Onyu (furosemide) – New drug approval
Trividia Health – Recall of Good Neighbor Pharmacy True Metrix® Self-Monitoring Blood glucose meters
October 10, 2025
RxNews - October 10, 2025
COVID-19 and Measles, Mumps, Rubella and Varicella (MMRV) vaccines – CDC Director adopts ACIP recommendations
Tecentriq® (atezolizumab) or Tecentriq Hybreza® (atezolizumab/hyaluronidase-tqjs) plus Zepzelca® (lurbinectedin) – New indication
Zoryve® (roflumilast) – Expanded indication, new strength
Eydenzelt® (aflibercept-boav) – New biosimilar approval
Jascayd® (nerandomilast) – New orphan drug approval
Qivigy® (immune globulin intravenous, human-kthm) – New drug approval
Rhapsido® (remibrutinib) – New drug approval
Grifols – Withdrawal of Gamunex®-C (immune globulin [human]) 10% injection
October 10, 2025
Optum Rx Managed Care Pharmacy Residency
A postgraduate managed care pharmacy residency program
October 3, 2025
RxNews - October 3, 2025
Caprelsa® (vandetanib) – Drug update (REMS removal)
Evkeeza® (evinacumab-dgnb) – Expanded indication
Tremfya® (guselkumab) – Expanded indications
Bondlido® (lidocaine) – New drug approval
Clotic (clotrimazole) – New drug approval
Enoby™ (denosumab-qbde) – New biosimilar approval
Inluriyo (imlunestrant) – New drug approval
Palsonify™ (paltusotine) – New orphan drug approval
Xtrenbo™ (denosumab-qbde) – New biosimilar approval
Endometrin® (progesterone) – First-time generic
September 26, 2025
RxNews - September 26, 2025
Aukelso™ (denosumab-kyqq) – New biosimilar approval
Bosaya™ (denosumab-kyqq) – New biosimilar approval
Forzinity™ (elamipretide) – New orphan drug approval
Keytruda Qlex™ (pembrolizumab/berahyaluronidase alfa-pmph) – New drug approval
Subvenite® (lamotrigine) – New drug approval
COVID-19, MMRV, and Hepatitis B vaccines – ACIP recommendations
Opzelura® (ruxolitinib) – Expanded indication
Tremfya® (guselkumab) – Updated dosing
Vyjuvek® (beremagene geperpavec-svdt) – Expanded indication
Dr. Reddy’s Laboratories – Withdrawal of ropinirole extended-release tablets
September 19, 2025
RxNews - September 19, 2025
Koselugo® (selumetinib) – Expanded indication, new formulation
Enbumyst™ (bumetanide) – New drug approval
Inlexzo™ (gemcitabine) – New drug approval
Zolymbus™ (bimatoprost) – New drug approval
Intercept – Withdrawal of Ocaliva® (obeticholic acid)
September 12, 2025
RxNews - September 12, 2025
Vonvendi® (von Willebrand factor [recombinant]) – Expanded indications
Otezla XR™ (apremilast) – New drug approval
September 5, 2025
RxNews - September 5, 2025
Bildyos® (denosumab-nxxp) – New biosimilar approval
Bilprevda® (denosumab-nxxp) – New biosimilar approval
Camcevi ETM® (leuprolide) – New formulation approval
Comirnaty® (COVID-19 vaccine, mRNA) – New vaccine approval
Leqembi® (lecanemab-irmb) – New formulation approval, updated drug monitoring
mNEXSPIKE® (COVID-19 vaccine, mRNA) – New vaccine approval
Nuvaxovid™ (COVID-19 vaccine, adjuvanted) – New vaccine approval
Spikevax® (COVID-19 vaccine, mRNA) – New vaccine approval
Wayrilz™ (rilzabrutinib) – New orphan drug approval
Unichem – Recall of cyclobenzaprine tablets
Saxenda® (liraglutide) – First-time generic
Tracleer® (bosentan) tablets for oral suspension – First-time generic
August 29, 2025
RxNews - August 29, 2025
Repatha® (evolocumab) – Expanded/updated indications
Thrombate III® (antithrombin III [human]) – Expanded indication
Cyklx™ (articaine) – New drug approval
Dawnzera™ (donidalorsen) – New orphan drug approval
Eligard® (leuprolide) – First-time authorized brand alternative
Ixchiq® (chikungunya vaccine, live) – FDA suspends biologics license
August 22, 2025
RxNews - August 22, 2025
Actemra® (tocilizumab) – Expanded indication
Wegovy® (semaglutide) – New indication
Papzimeos™ (zopapogene imadenovec-drba) – New drug approval
Tonmya™ (cyclobenzaprine) – New drug approval
Celltrion – Recall of Steqeyma® (ustekinumab-stba) injection
August 12, 2025
Brinsupri™ (brensocatib) – New drug approval
August 12, 2025 - Insmed announced the FDA approval of Brinsupri (brensocatib), for the treatment of non-cystic fibrosis bronchiectasis (NCFB) in adult and pediatric patients 12 years of age and older.
August 11, 2025
Venofer® (iron sucrose) – First-time generic
August 11, 2025 - Viatris launched an AB-rated generic version of American Regent’s Venofer (iron sucrose) injection.
August 8, 2025
Grifols – Withdrawal of Gamunex®-C (immune globulin [human]) 10% injection
August 8, 2025 - Grifols Therapeutics announced a voluntary, consumer level withdrawal of two lots of Gamunex-C (immune globulin [human]) 10% injection because of an increased rate of allergic/hypersensitivity type reactions.
August 8, 2025
Hernexeos® (zongertinib) – New drug approval
August 8, 2025 - The FDA announced the approval of Boehringer Ingelheim’s Hernexeos (zongertinib), for the treatment of adult patients with unresectable or metastatic non-squamous non-small cell lung cancer (NSCLC) whose tumors have HER2 (ERBB2) tyrosine kinase domain activating mutations, as detected by an FDA-approved test, and who have received prior systemic therapy.
August 7, 2025
Skysona® (elivaldogene autotemcel) – Updated labeling
August 7, 2025 - The FDA approved several labeling changes for Skysona (elivaldogene autotemcel) due to new safety information on the increased risk of hematologic malignancy.
August 6, 2025
Ixchiq® (Chikungunya vaccine, live) – FDA removes pause in use in patients 60 years and older
August 6, 2025 - The FDA removed the recommended pause in the use of Ixchiq (Chikungunya vaccine, live) in individuals 60 years of age and older and has approved updates to the prescribing information and patient information.
August 6, 2025
Ajovy® (fremanezumab-vfrm) – New indication
August 6, 2025 -Teva announced the FDA approval of Ajovy (fremanezumab-vfrm), for the preventive treatment of episodic migraine in pediatric patients who are 6 to 17 years of age and who weigh 45 kg or more.
August 6, 2025
Vuity® (pilocarpine) – First-time generic
August 6, 2025 - Amneal launched an AB-rated generic version of AbbVie’s Vuity (pilocarpine) ophthalmic solution.
August 6, 2025
Modeyso™ (dordaviprone) – New orphan drug approval
August 6, 2025 - The FDA announced the approval of Jazz Pharmaceuticals’ Modeyso (dordaviprone), for the treatment of adult and pediatric patients 1 year of age and older with diffuse midline glioma harboring an H3 K27M mutation with progressive disease following prior therapy.
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